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NFL Week 6 Odds and Lines: Compare Kalshi and Polymarket Predictions

Compare Kalshi and Polymarket US prices across all 14 Week 6 NFL matchups, including early favorites, competitive games, and the latest available spreads and totals.

NFL Week 6 Prediction Markets: Latest prices from Kalshi and Polymarket

Week 6 opens Thursday, October 15, when the Seattle Seahawks (57%) visit the Denver Broncos (46%). Sunday's schedule begins with the Houston Texans (40%) against the Jacksonville Jaguars (62%) in London, followed by a full afternoon slate.

The Sunday night matchup is Dallas Cowboys (55%) vs. Green Bay Packers (48%), while the Washington Commanders (22%) and San Francisco 49ers (80%) close the week on Monday night. Below are Week 6 odds and predictions directly from Kalshi and Polymarket US.

NFL Week 6 odds: Compare lines and totals for every game updated daily

The table below compares early Week 6 winner-market prices from Kalshi and Polymarket US. Prices are subject to change as Week 5 concludes and trading activity increases.

Week 6 odds, spread, and moneyline at Kalshi

Seattle Seahawks at Denver Broncos — Thursday, October 15

Time: 8:15 p.m. ET | TV: Prime Video | Venue: Empower Field at Mile High

TeamKalshi spreadKalshi moneylineKalshi O/U
Seattle Seahawks-2.5 (51%)57%Over 41.5 (51%)
Denver BroncosTBD46%Under 41.5 (TBD)

Seattle enters Week 5 at 3-1, while Denver sits at 2-2 after losing to San Francisco in Week 4. The Seahawks are narrow road favorites for Thursday's opener. The early spread market suggests a competitive game, factoring in Denver's home-field advantage and the short turnaround.

Houston Texans at Jacksonville Jaguars — Sunday, October 18

Time: 9:30 a.m. ET | TV: NFL Network | Venue: Wembley Stadium, London

TeamKalshi spreadKalshi moneylineKalshi O/U
Houston TexansTBD40%TBD
Jacksonville JaguarsTBD62%TBD

Jacksonville heads into Week 5 at 3-1 following a road victory over Cincinnati, while Houston remains winless after a 34-30 loss to Dallas. The AFC South rivals meet in London, where the Jaguars have extensive experience playing international games. Jacksonville holds the early market advantage for its second straight overseas game.

Baltimore Ravens at Cleveland Browns — Sunday, October 18

Time: 1 p.m. ET | TV: FOX | Venue: Huntington Bank Field

TeamKalshi spreadKalshi moneylineKalshi O/U
Baltimore RavensTBD64%TBD
Cleveland BrownsTBD37%TBD

Both AFC North rivals enter Week 5 at 3-1, making this one of the more intriguing divisional matchups on the schedule. Baltimore comes off a 24-18 victory over Tennessee, while Cleveland has also built a strong early-season record. The Ravens carry a clear market advantage despite traveling to face a better-than-expected Browns team.

Carolina Panthers at Philadelphia Eagles — Sunday, October 18

Time: 1 p.m. ET | TV: CBS | Venue: Lincoln Financial Field

TeamKalshi spreadKalshi moneylineKalshi O/U
Carolina PanthersTBD50%TBD
Philadelphia EaglesTBD50%TBD

Carolina and Philadelphia enter Week 5 with matching 2-2 records, and the early Week 6 market is evenly divided. The Panthers are coming off a 32-26 victory over Detroit, while the Eagles lost 24-20 to the Rams. Philadelphia has the home-field advantage, but will be returning from a London matchup versus the Jaguars.

Chicago Bears at Atlanta Falcons — Sunday, October 18

Time: 1 p.m. ET | TV: FOX | Venue: Mercedes-Benz Stadium

TeamKalshi spreadKalshi moneylineKalshi O/U
Chicago BearsTBD57%TBD
Atlanta FalconsTBD46%TBD

Chicago enters Week 5 at 3-1 after defeating the Jets, while Atlanta is 2-2 following an emphatic 45-24 Monday night victory over New Orleans. The Bears are modest road favorites in the early market, setting up an interesting test against a Falcons team coming off its strongest offensive showing of the season.

Tennessee Titans at Indianapolis Colts — Sunday, October 18

Time: 1 p.m. ET | TV: FOX | Venue: Lucas Oil Stadium

TeamKalshi spreadKalshi moneylineKalshi O/U
Tennessee TitansTBD28%TBD
Indianapolis ColtsTBD74%TBD

Indianapolis is a substantial favorite against its AFC South rival, with Tennessee still searching for its first victory entering Week 5. The Colts improved to 2-2 with a convincing 30-13 win over Washington, while the Titans fell to 0-4 following a loss in Baltimore. Indianapolis will look to build on that result, with the early market reflecting the gap between the teams' starts.

Pittsburgh Steelers at Tampa Bay Buccaneers — Sunday, October 18

Time: 1 p.m. ET | TV: CBS | Venue: Raymond James Stadium

TeamKalshi spreadKalshi moneylineKalshi O/U
Pittsburgh SteelersTBD57%TBD
Tampa Bay BuccaneersTBD46%TBD

Pittsburgh enters Week 5 at 2-2, while Tampa Bay improved to 1-4 following Thursday night's 24-16 win over Dallas. The Buccaneers will have extra time to prepare for this matchup, but their early-season struggles have left Pittsburgh as a modest road favorite. The Steelers' Week 5 game against Indianapolis will provide additional insight before the trip to Tampa.

New Orleans Saints at New York Giants — Sunday, October 18

Time: 1 p.m. ET | TV: FOX | Venue: MetLife Stadium

TeamKalshi spreadKalshi moneylineKalshi O/U
New Orleans SaintsTBD54%TBD
New York GiantsTBD49%TBD

New Orleans enters Week 5 at 1-3 after surrendering 45 points to Atlanta on Monday night, while the Giants are 3-1 following a 36-24 victory over Arizona. Despite the difference in records, the Saints are slight road favorites in the early Week 6 market, but prices could be on the move based on what both sides deliver on Sunday.

New York Jets at New England Patriots — Sunday, October 18

Time: 1 p.m. ET | TV: CBS | Venue: Gillette Stadium

TeamKalshi spreadKalshi moneylineKalshi O/U
New York JetsTBD27%TBD
New England PatriotsTBD76%TBD

New England is a heavy favorite in this AFC East matchup after handing Buffalo its first loss of the season in Week 4. The Patriots enter Week 5 at 2-2, while the Jets are 1-3 following a 23-12 defeat against Chicago. The divisional rivalry adds some intrigue, but the early market gives New England a substantial advantage at home.

Arizona Cardinals at Los Angeles Rams — Sunday, October 18

Time: 4:05 p.m. ET | TV: FOX | Venue: SoFi Stadium

TeamKalshi spreadKalshi moneylineKalshi O/U
Arizona CardinalsTBD16%TBD
Los Angeles RamsTBD86%TBD

The Rams are the biggest favorite on the Week 6 board, despite entering Week 5 with a 2-2 record. Los Angeles is coming off a 24-20 road victory over Philadelphia, while Arizona fell to 1-3 after losing to the Giants. The NFC West rivals meet at SoFi Stadium, where the market expects the Rams to hold a commanding advantage. Los Angeles faces Buffalo on MNF in Week 5 before turning its attention to Arizona.

Buffalo Bills at Las Vegas Raiders — Sunday, October 18

Time: 4:25 p.m. ET | TV: CBS | Venue: Allegiant Stadium

TeamKalshi spreadKalshi moneylineKalshi O/U
Buffalo BillsTBD71%TBD
Las Vegas RaidersTBD32%TBD

Buffalo enters Week 5 at 3-1 after a narrow 29-26 loss to New England, while Las Vegas also sits at 3-1 following a 30-27 defeat against Kansas City. Despite their matching records, the Bills are clear road favorites. Buffalo faces another significant test against the Rams on Monday night before traveling to Las Vegas, the result of which could have bearing on Week 6 prices.

Los Angeles Chargers at Kansas City Chiefs — Sunday, October 18

Time: 4:25 p.m. ET | TV: CBS | Venue: Arrowhead Stadium

TeamKalshi spreadKalshi moneylineKalshi O/U
Los Angeles ChargersTBD21%TBD
Kansas City ChiefsTBD80%TBD

Kansas City enters Week 5 undefeated at 4-0, while the Chargers are still looking for their first victory. The Chiefs survived a 30-27 contest against Las Vegas in Week 4, while Los Angeles lost 30-23 to Seattle. The AFC West rivals meet at Arrowhead Stadium, with Kansas City holding one of the largest market advantages of Week 6. The Chiefs have a Week 5 bye.

Dallas Cowboys at Green Bay Packers — Sunday, October 18

Time: 8:20 p.m. ET | TV: NBC | Venue: Lambeau Field

TeamKalshi spreadKalshi moneylineKalshi O/U
Dallas CowboysTBD55%TBD
Green Bay PackersTBD48%TBD

Dallas fell to 2-3 with a 24-16 Thursday night loss to Tampa Bay, while Green Bay enters Week 5 at 2-2 following a 17-14 win against the Buccaneers. The Cowboys are slight road favorites for this Sunday Night Football matchup. Green Bay still has a divisional matchup against Chicago ahead, while Dallas will have extra preparation time following its Thursday game.

Washington Commanders at San Francisco 49ers — Monday, October 19

Time: 8:15 p.m. ET | TV: ESPN | Venue: Levi's Stadium

TeamKalshi spreadKalshi moneylineKalshi O/U
Washington CommandersTBD22%TBD
San Francisco 49ersTBD80%TBD

San Francisco enters Week 5 undefeated at 4-0 after beating Denver 24-14, while Washington is 1-3 following a 30-13 loss to Indianapolis. The 49ers are substantial home favorites for Monday Night Football, with the early market giving Washington little room for error. San Francisco faces NFC West rival Seattle in Week 5, while the Commanders meet the Giants before heading west.

Notable NFL Week 6 line moves

Week 6 pricing is still in its early stages, with most teams yet to complete their Week 5 games. The current Kalshi and Polymarket US prices provide a baseline for tracking movement as results come in and additional spread and total markets become available.

Several matchups stand out for their competitive early pricing, including Panthers–Eagles, Cowboys–Packers, and Seahawks–Broncos. Meanwhile, the Rams, Chiefs, and 49ers have opened as substantial favorites.

The most meaningful price changes could emerge following Sunday's games and Monday night's Bills–Rams matchup. We'll update this section as Week 6 markets develop.

NFL futures market outlook

The Los Angeles Rams lead Kalshi's Super Bowl LXI prediction market at 12%, followed by the Buffalo Bills at 11%. The Kansas City Chiefs and San Francisco 49ers are tied at 10%, with the Seattle Seahawks close behind at 9%.

The NFL MVP market is particularly competitive. San Francisco quarterback Brock Purdy leads at 21%, narrowly ahead of Buffalo's Josh Allen at 20%. Patrick Mahomes sits third at 11%, followed by Trevor Lawrence (9%) and Joe Burrow (8%).

Purdy has gained three percentage points, while Allen has dropped seven, according to Kalshi's displayed market movement. That gives us a meaningful storyline to monitor as Week 5 unfolds.

Readers can compare prediction market apps and review current NFL promos before choosing where to trade Week 6 and season-long contracts.

You can also print a Week 6 pick-em sheet.

Where the money is going on Week 6, with the biggest trades and the most-traded player props: NFL Week 6 predictions.