NFL Week 5 Odds: Latest Prices from Kalshi and Polymarket

Week 5 begins Thursday, Oct. 8, with the Buccaneers (18%) visiting the Cowboys (82%). Philadelphia (42%) and Jacksonville kick off Sunday in London at 9:30 a.m. ET, with the Jaguars holding an early 59% edge.

Sunday's slate includes several closely priced games, including Bears (46%) vs. Packers (54%), before the Ravens (71%) visit the Falcons (32%) on Sunday night. The week closes with Bills (45%) vs. Rams (54%) on Monday night. Below are Week 5 odds and predictions directly from Kalshi and Polymarket US.

NFL Week 5 odds: Compare lines and totals for every game updated daily

Below are the matchup prices from Kalshi and Polymarket US.

Week 5 odds, spread, and moneyline at Kalshi

Tampa Bay Buccaneers @ Dallas Cowboys | Thursday, Oct. 8 | 8:15 p.m. ET | Prime Video | AT&T Stadium, Arlington, TX |

Dallas enters Week 5 as one of the largest favorites on the board. The Cowboys were 1-2 heading into Sunday's game at Houston, while Tampa Bay entered its matchup with Green Bay looking for its first win. Baker Mayfield's injured right thumb is a situation to watch on a short week for the Buccaneers.

Philadelphia Eagles @ Jacksonville Jaguars | Sunday, Oct. 11 | 9:30 a.m. ET | NFL work | Tottenham Hotspur Stadium, London |

Philadelphia and Jacksonville head to London after both entering Week 4 at 2-1. The Jaguars routed New England 35-6 in Week 3 behind three Trevor Lawrence touchdown passes, while Philadelphia is looking to stabilize after a 27-7 loss to Chicago. Jacksonville holds the early market edge in a neutral-site matchup between two teams with postseason expectations.

Las Vegas Raiders @ New England Patriots | Sunday, Oct. 11 | 1 p.m. ET | CBS | Gillette Stadium, Foxborough, MA |

Las Vegas has been one of the NFL's early surprises, taking a 3-0 record into its Week 4 showdown with Kansas City. New England entered Sunday at 1-2 after a 35-6 loss at Jacksonville. Despite the difference in records, Kalshi gives the Patriots a clear home-field edge at 63%, making this one of the more interesting early Week 5 prices.

Houston Texans @ Tennessee Titans | Sunday, Oct. 11 | 1 p.m. ET | CBS | Nissan Stadium, Nashville, TN |

Houston and Tennessee both entered Week 4 at 0-3, but the market sees a sizable gap between the AFC South rivals. The Texans suffered another close loss in Week 3, falling 19-17 at Indianapolis, while Tennessee scored just seven points against the Giants. Kalshi pricing points to Houston as a sizable road favorite.

Cleveland Browns @ New York Jets | Sunday, Oct. 11 | 1 p.m. ET | CBS | MetLife Stadium, East Rutherford, NJ |

Cleveland improved to 3-1 with a 27-24 Thursday night win over Pittsburgh. The Browns now head to New York for a matchup the market views as essentially a toss-up. The Jets entered Week 4 at 1-2, but Kalshi gives them a slight 52% edge at home.

New York Giants @ Washington Commanders | Sunday, Oct. 11 | 1 p.m. ET | FOX | Northwest Stadium, Landover, MD |

The NFC East rivals meet for the first time this season with Washington opening as the favorite. The Giants entered Week 4 at 2-1 after beating Tennessee behind Jameis Winston, who took over following Jaxson Dart's season-ending injury. Washington's quarterback situation is a key angle, with Jayden Daniels sidelined and Marcus Mariota starting in his place.

Minnesota Vikings @ New Orleans Saints | Sunday, Oct. 11 | 1 p.m. ET | FOX | Caesars Superdome, New Orleans, LA |

Minnesota carried a 3-0 record into Week 4, but traders aren't treating a trip to New Orleans as a layup. The Saints entered Monday night's game against Atlanta at 1-2 after committing four fourth-quarter turnovers in a loss to Las Vegas. Minnesota is only a modest 55% favorite, leaving little separation between the two teams.

Cincinnati Bengals @ Miami Dolphins | Sunday, Oct. 11 | 1 p.m. ET | FOX | Hard Rock Stadium, Miami Gardens, FL |

Cincinnati is tied with Dallas as the strongest early Week 5 favorite. The Bengals entered Week 4 at 2-1, while Miami remained winless after a 24-10 loss to Kansas City. The Dolphins had a league-worst minus-50 point differential through three games, helping explain why Cincinnati is priced at 82% despite playing on the road.

Indianapolis Colts @ Pittsburgh Steelers | Sunday, Oct. 11 | 1 p.m. ET | CBS | Acrisure Stadium, Pittsburgh, PA |

Pittsburgh has extra time to prepare after its 27-24 Thursday night loss at Cleveland dropped the Steelers to 2-2. Indianapolis entered Sunday's London game against Washington at 1-2 after earning its first win of the season against Houston. Kalshi gives Pittsburgh a modest edge at home, but the Colts' Week 4 result could shift the market.

Chicago Bears @ Green Bay Packers | Sunday, Oct. 11 | 4:25 p.m. ET | FOX | Lambeau Field, Green Bay, WI |

One of the NFL's oldest rivalries returns with the market almost evenly divided. Chicago entered Week 4 at 2-1 after routing Philadelphia 27-7, while Green Bay came into Sunday's game at Tampa Bay at 1-2. The Packers are only a 54% favorite at Lambeau Field, making this one of the tightest early Week 5 markets.

Denver Broncos @ Los Angeles Chargers | Sunday, Oct. 11 | 4:05 p.m. ET | CBS | SoFi Stadium, Inglewood, CA |

Denver entered Week 4 at 2-1 after rallying from a 16-point halftime deficit to beat the Rams. The Chargers opened 0-3 after losses to Kansas City, Las Vegas, and Buffalo. Despite playing on the road, the Broncos hold the early market advantage at 57% in the first meeting of the season between the AFC West rivals.

Detroit Lions @ Arizona Cardinals | Sunday, Oct. 11 | 4:25 p.m. ET | FOX | State Farm Stadium, Glendale, AZ |

Detroit entered Week 4 at 2-1 after Jahmyr Gibbs scored three second-half touchdowns in a win over the Jets. Arizona was 1-2 heading into Sunday's game against the Giants after consecutive losses to Seattle and San Francisco. Kalshi gives Detroit a 70% chance to win on the road, putting the Lions among the stronger favorites on Sunday's slate.

San Francisco 49ers @ Seattle Seahawks | Sunday, Oct. 11 | 4:25 p.m. ET | FOX | Lumen Field, Seattle, WA |

San Francisco and Seattle renew their NFC West rivalry in one of the more intriguing Week 5 matchups. The 49ers entered Week 4 unbeaten after Brock Purdy threw four touchdowns against Arizona, while the defending Super Bowl champion Seahawks came in at 2-1. Kalshi currently gives Seattle a 63% chance to win at home.

Baltimore Ravens @ Atlanta Falcons | Sunday, Oct. 11 | 8:20 p.m. ET | NBC | Mercedes-Benz Stadium, Atlanta, GA |

Sunday Night Football sends Baltimore to Atlanta, where the Ravens are already drawing significant market support. Baltimore entered Week 4 at 2-1 after beating Dallas 34-31 in Brazil. Atlanta improved to 1-2 with a 35-14 win over Green Bay and faces New Orleans on Monday night before turning around to prepare for Lamar Jackson and the Ravens.

Buffalo Bills @ Los Angeles Rams | Monday, Oct. 12 | 8:15 p.m. ET | ESPN/ABC | SoFi Stadium, Inglewood, CA |

Week 5 closes with one of the most interesting opening prices on the board. Buffalo entered Week 4 at 3-0 and sits atop the Super Bowl market, while Los Angeles was the preseason favorite and carried a 1-2 record into Sunday's game at Philadelphia. Even so, Kalshi makes the Rams a slight home favorite. Both teams' Week 4 results could make this one of the more active markets to watch.

Notable Week 5 line moves

Week 5 pricing is still in its opening stages, with most teams yet to complete their Week 4 games. The current prices will serve as the baseline for tracking movement throughout the week.

Several markets are already tightly priced. Cleveland-New York sits at 48%-52%, Green Bay holds only a narrow edge over Chicago, and Minnesota is a modest favorite at New Orleans. Buffalo opening as an underdog at Los Angeles is another market worth watching as Week 4 results come in.

NFL futures market outlook

Buffalo currently leads the Kalshi 2027 Super Bowl winner market at 13%, followed by the Rams at 11% and San Francisco at 9%.

That creates an interesting backdrop for Week 5's Monday night matchup between Buffalo and Los Angeles. The Bills and Rams currently occupy the top two spots in the championship market, even though Los Angeles entered Week 4 with a 1-2 record.

Josh Allen remains the leader in the Kalshi 2026-27 NFL MVP market at 24%, followed by Brock Purdy at 18% and Lamar Jackson at 11%.

The futures board could shift considerably once Week 4 is complete, with Buffalo, San Francisco, Baltimore, and several other contenders still in action.

Readers can compare prediction market apps and review current NFL promos before choosing where to trade Week 5 and season-long contracts. You can also print a Week 5 pick-em sheet.