NFL Week 1 Predictions: Daily Updates and Odds

Author ... Christopher Feery
Christopher Feery

Christopher has been writing professionally since 2014, with a focus on casinos and sports betting. After New Jersey legalized sports betting in 2018, he shifted his full attention to the gambling industry, joining Caten...

Atlanta will start Cooper Rush after ruling out Tua Tagovailoa and Michael Penix Jr., while Pittsburgh moved from a 5.5-point to a 6.5-point favorite and the Falcons’ Kalshi win price fell two percentage points to 30%. Cowboys vs. Giants was Sunday’s most-traded matchup with $797,954 in Kalshi game composite volume as of 7:00 a.m. ET on Sept. 12. Among the weekend’s closest-priced game-winner markets, Bills vs. Texans had Buffalo at 52% and Houston at 48% on Kalshi.

Week 1 continues with 14 games across the weekend and Monday night. Sunday’s slate includes Bills 52% (-108) vs. Texans 48% (+108) and Falcons 30% (+233) vs. Steelers 71% (-245) in the early window, followed by Cowboys 61% (-156) vs. Giants 40% (+150) on Sunday Night Football.

Broncos 45% (+122) vs. Chiefs 56% (-127) closes Week 1 on Monday Night Football. Here are the latest Week 1 odds and predictions, pulled directly from Kalshi, Polymarket, FanDuel, and DraftKings.

Week 1 matchups and current odds

88 sides across 16 games, prices from Kalshi, Polymarket US, FanDuel and DraftKings, updated Sep 9, 4:16pm ET.

Tap any price to trade it. Kalshi best on 14 of 28 sides Polymarket US best on 23 of 28 sides Polymarket US best on 20 of 28 sides Polymarket US best on 53 of 84 sides

FanDuel Predicts and DraftKings Predictions do not offer NFL contracts in states with regulated online sportsbooks. Kalshi and Polymarket US remain available. Odds are shown for all operators so you can compare who has the best price.

None of these venues offer NFL event contracts in Nevada. Odds are shown for reference only.

Game KalshiiDeposit and trade at least $10 on Kalshi within your first 90 days and get a $25 trading bonus. The bonus is available for trade only and is not cashable. Must be used within 7 days. Eligible US states only. Trade $10, Get $25 Polymarket USi18+ Only. Restrictions and eligibility requirements apply. Not available in all jurisdictions. Trading is risky. 100% loss can occur. See polymarket.com/tos for more information. The Polymarket US App serves as an independent software provider and affiliate of Polymarket US and Polymarket Clearing, the CFTC-regulated exchange and clearing organization. Deposit $10 get a $50 trading bonus FanDueliRequires $1 trade over five days. The bonus itself is non-withdrawable, but winnings from bonus-funded trades are immediately withdrawable. If the bonus trade wins, you keep the winnings portion but not the original bonus stake. Must be 18+ Trade $5, Get $100 DraftKingsiIn partnership with DraftKings. T&Cs Apply. View full offer terms before trading. Full disclaimer here: Event Contract Trading is offered by DraftKings Predictions, a CFTC-registered Futures Commission Merchant and NFA member. Trading involves substantial risk of loss and is not suitable for everyone. Market availability varies. Eligibility restrictions apply. 1 per new DraftKings customer. $5+ first-time trade req. Max. $200 issued as non-withdrawable Predictions Dollars that expire in 1 year. Reward issued as $50 in Predictions Dollars every 7 days via click-to-claim for 21 days. Click-to-claims expire 7 days after issuance. 7 days = 168hrs. Terms: dkng.co/predictionspromo. Ends 9/20/26 at 11:59 PM ET. Sponsored by DK. Spend $5+, Get $200 in Bonuses (Paid Over 21 Days)
Bills @ Texans · CBS
Spread odds for Buffalo Bills at Houston Texans by operator
TeamKalshiPolymarket USFanDuelDraftKings
BUFBuffalo BillsSPREADSpread K Best −1.5 -105 $100 → $195 Not available P Best −1.5 -104 $100 → $196 Not available FDNot listed DKNot listed
HOUHouston TexansSPREADSpread K Best +1.5 -109 $100 → $191 Not available P Best +1.5 -108 $100 → $192 Not available FDNot listed DKNot listed
Total odds for Buffalo Bills at Houston Texans by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 44.5O/UTotal (Over/Under) K Best 44.5 -105 $100 → $195 Not available P Best 44.5 -104 $100 → $196 Not available FDNot listed DKNot listed
UUnder 44.5O/UTotal (Over/Under) K Best 44.5 -109 $100 → $191 Not available P Best 44.5 -108 $100 → $192 Not available FDNot listed DKNot listed
Bears @ Panthers · FOX
Spread odds for Chicago Bears at Carolina Panthers by operator
TeamKalshiPolymarket USFanDuelDraftKings
CHIChicago BearsSPREADSpread K Best −2.5 -128 $100 → $178 Not available P Best −2.5 -127 $100 → $179 Not available FDNot listed DKNot listed
CARCarolina PanthersSPREADSpread K Best +2.5 +112 $100 → $212 Not available P Best +2.5 +113 $100 → $213 Not available FDNot listed DKNot listed
Total odds for Chicago Bears at Carolina Panthers by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 46.5O/UTotal (Over/Under) K Best 46.5 -114 $100 → $188 Not available P Best 46.5 -113 $100 → $189 Not available FDNot listed DKNot listed
UUnder 46.5O/UTotal (Over/Under) K Best 46.5 -101 $100 → $199 Not available P Best 46.5 +100 $100 → $200 Not available FDNot listed DKNot listed
Jets @ Titans · CBS
Spread odds for New York Jets at Tennessee Titans by operator
TeamKalshiPolymarket USFanDuelDraftKings
NYJNew York JetsSPREADSpread K +1.5 -114 $100 → $188 Not available P Best −0.5 -108 $100 → $192 Not available FDNot listed DKNot listed
TENTennessee TitansSPREADSpread K Best −1.5 -101 $100 → $199 Not available P +0.5 -104 $100 → $196 Not available FDNot listed DKNot listed
Total odds for New York Jets at Tennessee Titans by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 38.5O/UTotal (Over/Under) K Best 38.5 -114 $100 → $188 Not available P Best 38.5 -113 $100 → $189 Not available FDNot listed DKNot listed
UUnder 38.5O/UTotal (Over/Under) K Best 38.5 -101 $100 → $199 Not available P Best 38.5 +100 $100 → $200 Not available FDNot listed DKNot listed
Falcons @ Steelers · FOX
Spread odds for Atlanta Falcons at Pittsburgh Steelers by operator
TeamKalshiPolymarket USFanDuelDraftKings
ATLAtlanta FalconsSPREADSpread K Best +6.5 -114 $100 → $188 Not available P Best +6.5 -113 $100 → $189 Not available FDNot listed DKNot listed
PITPittsburgh SteelersSPREADSpread K Best −6.5 -101 $100 → $199 Not available P Best −6.5 +100 $100 → $200 Not available FDNot listed DKNot listed
Total odds for Atlanta Falcons at Pittsburgh Steelers by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 40.5O/UTotal (Over/Under) K Best 40.5 -109 $100 → $191 Not available P Best 40.5 -108 $100 → $192 Not available FDNot listed DKNot listed
UUnder 40.5O/UTotal (Over/Under) K Best 40.5 -105 $100 → $195 Not available P Best 40.5 -104 $100 → $196 Not available FDNot listed DKNot listed
Browns @ Jaguars · CBS
Spread odds for Cleveland Browns at Jacksonville Jaguars by operator
TeamKalshiPolymarket USFanDuelDraftKings
CLECleveland BrownsSPREADSpread K +9.5 -114 $100 → $188 Not available P Best +8.5 -104 $100 → $196 Not available FDNot listed DKNot listed
JAXJacksonville JaguarsSPREADSpread K Best −9.5 -101 $100 → $199 Not available P −8.5 -108 $100 → $192 Not available FDNot listed DKNot listed
Total odds for Cleveland Browns at Jacksonville Jaguars by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 40.5O/UTotal (Over/Under) K Best 40.5 -101 $100 → $199 Not available P Best 40.5 +100 $100 → $200 Not available FDNot listed DKNot listed
UUnder 40.5O/UTotal (Over/Under) K Best 40.5 -114 $100 → $188 Not available P Best 40.5 -113 $100 → $189 Not available FDNot listed DKNot listed
Buccaneers @ Bengals · FOX
Spread odds for Tampa Bay Buccaneers at Cincinnati Bengals by operator
TeamKalshiPolymarket USFanDuelDraftKings
TBTampa Bay BuccaneersSPREADSpread K Best +3.5 -105 $100 → $195 Not available P Best +3.5 -104 $100 → $196 Not available FDNot listed DKNot listed
CINCincinnati BengalsSPREADSpread K Best −3.5 -109 $100 → $191 Not available P Best −3.5 -108 $100 → $192 Not available FDNot listed DKNot listed
Total odds for Tampa Bay Buccaneers at Cincinnati Bengals by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 50.5O/UTotal (Over/Under) K Best 50.5 -101 $100 → $199 Not available P 49.5 -113 $100 → $189 Not available FDNot listed DKNot listed
UUnder 50.5O/UTotal (Over/Under) K 50.5 -114 $100 → $188 Not available P Best 49.5 +100 $100 → $200 Not available FDNot listed DKNot listed
Saints @ Lions · FOX
Spread odds for New Orleans Saints at Detroit Lions by operator
TeamKalshiPolymarket USFanDuelDraftKings
NONew Orleans SaintsSPREADSpread K +7.5 -126 $100 → $179 Not available P Best +6.5 +113 $100 → $213 Not available FDNot listed DKNot listed
DETDetroit LionsSPREADSpread K Best −7.5 +109 $100 → $209 Not available P −6.5 -127 $100 → $179 Not available FDNot listed DKNot listed
Total odds for New Orleans Saints at Detroit Lions by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 49.5O/UTotal (Over/Under) K Best 49.5 -114 $100 → $188 Not available P Best 49.5 -113 $100 → $189 Not available FDNot listed DKNot listed
UUnder 49.5O/UTotal (Over/Under) K Best 49.5 -101 $100 → $199 Not available P Best 49.5 +100 $100 → $200 Not available FDNot listed DKNot listed
Ravens @ Colts · CBS
Spread odds for Baltimore Ravens at Indianapolis Colts by operator
TeamKalshiPolymarket USFanDuelDraftKings
BALBaltimore RavensSPREADSpread K Best −3.5 +112 $100 → $212 Not available P Best −3.5 +113 $100 → $213 Not available FDNot listed DKNot listed
INDIndianapolis ColtsSPREADSpread K Best +3.5 -128 $100 → $178 Not available P Best +3.5 -127 $100 → $179 Not available FDNot listed DKNot listed
Total odds for Baltimore Ravens at Indianapolis Colts by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 47.5O/UTotal (Over/Under) K 47.5 -114 $100 → $188 Not available P Best 48.5 +104 $100 → $204 Not available FDNot listed DKNot listed
UUnder 47.5O/UTotal (Over/Under) K Best 47.5 -101 $100 → $199 Not available P 48.5 -117 $100 → $185 Not available FDNot listed DKNot listed
Packers @ Vikings · CBS
Spread odds for Green Bay Packers at Minnesota Vikings by operator
TeamKalshiPolymarket USFanDuelDraftKings
GBGreen Bay PackersSPREADSpread K +2.5 -112 $100 → $190 Not available P Best +1.5 +100 $100 → $200 Not available FDNot listed DKNot listed
MINMinnesota VikingsSPREADSpread K Best −2.5 -103 $100 → $197 Not available P −1.5 -113 $100 → $189 Not available FDNot listed DKNot listed
Total odds for Green Bay Packers at Minnesota Vikings by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 46.5O/UTotal (Over/Under) K Best 46.5 -101 $100 → $199 Not available P 45.5 -113 $100 → $189 Not available FDNot listed DKNot listed
UUnder 46.5O/UTotal (Over/Under) K 46.5 -114 $100 → $188 Not available P Best 45.5 +100 $100 → $200 Not available FDNot listed DKNot listed
Commanders @ Eagles · FOX
Spread odds for Washington Commanders at Philadelphia Eagles by operator
TeamKalshiPolymarket USFanDuelDraftKings
WASWashington CommandersSPREADSpread K Best +5.5 -101 $100 → $199 Not available P Best +5.5 +100 $100 → $200 Not available FDNot listed DKNot listed
PHIPhiladelphia EaglesSPREADSpread K Best −5.5 -114 $100 → $188 Not available P Best −5.5 -113 $100 → $189 Not available FDNot listed DKNot listed
Total odds for Washington Commanders at Philadelphia Eagles by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 44.5O/UTotal (Over/Under) K Best 44.5 +107 $100 → $207 Not available P 43.5 -113 $100 → $189 Not available FDNot listed DKNot listed
UUnder 44.5O/UTotal (Over/Under) K 44.5 -123 $100 → $181 Not available P Best 43.5 +100 $100 → $200 Not available FDNot listed DKNot listed
Cardinals @ Chargers
Moneyline odds for Arizona Cardinals at Los Angeles Chargers by operator
TeamKalshiPolymarket USFanDuelDraftKings
ARIArizona CardinalsMLMoneyline K Best +411 $100 → $511 Not available P +409 $100 → $509 Not available FDNot listed DKNot listed
LACLos Angeles ChargersMLMoneyline K Best -443 $100 → $123 Not available P -461 $100 → $122 Not available FDNot listed DKNot listed
Spread odds for Arizona Cardinals at Los Angeles Chargers by operator
TeamKalshiPolymarket USFanDuelDraftKings
ARIArizona CardinalsSPREADSpread K +9.5 -114 $100 → $188 Not available P Best +8.5 +100 $100 → $200 Not available FDNot listed DKNot listed
LACLos Angeles ChargersSPREADSpread K Best −9.5 -101 $100 → $199 Not available P −8.5 -113 $100 → $189 Not available FDNot listed DKNot listed
Total odds for Arizona Cardinals at Los Angeles Chargers by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 47.5O/UTotal (Over/Under) K Best 47.5 -101 $100 → $199 Not available P 46.5 -117 $100 → $185 Not available FDNot listed DKNot listed
UUnder 47.5O/UTotal (Over/Under) K 47.5 -114 $100 → $188 Not available P Best 46.5 +104 $100 → $204 Not available FDNot listed DKNot listed
All markets odds for Arizona Cardinals at Los Angeles Chargers by operator
TeamKalshiPolymarket USFanDuelDraftKings
ARIArizona Cardinals K ML +411 SP +9.5 -114 TO o47.5 -101 P ML +409 SP +8.5 +100 TO o46.5 -117 FDNot listed DKNot listed
LACLos Angeles Chargers K ML -443 SP −9.5 -101 TO u47.5 -114 P ML -461 SP −8.5 -113 TO u46.5 +104 FDNot listed DKNot listed
Dolphins @ Raiders
Moneyline odds for Miami Dolphins at Las Vegas Raiders by operator
TeamKalshiPolymarket USFanDuelDraftKings
MIAMiami DolphinsMLMoneyline K Best +143 $100 → $243 Not available P +143 $100 → $243 Not available FDNot listed DKNot listed
LVLas Vegas RaidersMLMoneyline K -164 $100 → $161 Not available P Best -161 $100 → $162 Not available FDNot listed DKNot listed
Spread odds for Miami Dolphins at Las Vegas Raiders by operator
TeamKalshiPolymarket USFanDuelDraftKings
MIAMiami DolphinsSPREADSpread K Best +3.5 -123 $100 → $181 Not available P Best +3.5 -122 $100 → $182 Not available FDNot listed DKNot listed
LVLas Vegas RaidersSPREADSpread K Best −3.5 +107 $100 → $207 Not available P Best −3.5 +108 $100 → $208 Not available FDNot listed DKNot listed
Total odds for Miami Dolphins at Las Vegas Raiders by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 40.5O/UTotal (Over/Under) K Best 40.5 -101 $100 → $199 Not available P 40.5 -104 $100 → $196 Not available FDNot listed DKNot listed
UUnder 40.5O/UTotal (Over/Under) K 40.5 -114 $100 → $188 Not available P Best 40.5 -108 $100 → $192 Not available FDNot listed DKNot listed
All markets odds for Miami Dolphins at Las Vegas Raiders by operator
TeamKalshiPolymarket USFanDuelDraftKings
MIAMiami Dolphins K ML +143 SP +3.5 -123 TO o40.5 -101 P ML +143 SP +3.5 -122 TO o40.5 -104 FDNot listed DKNot listed
LVLas Vegas Raiders K ML -164 SP −3.5 +107 TO u40.5 -114 P ML -161 SP −3.5 +108 TO u40.5 -108 FDNot listed DKNot listed
Cowboys @ Giants
Moneyline odds for Dallas Cowboys at New York Giants by operator
TeamKalshiPolymarket USFanDuelDraftKings
DALDallas CowboysMLMoneyline K -164 $100 → $161 Not available P Best -161 $100 → $162 Not available FDNot listed DKNot listed
NYGNew York GiantsMLMoneyline K Best +143 $100 → $243 Not available P +143 $100 → $243 Not available FDNot listed DKNot listed
Spread odds for Dallas Cowboys at New York Giants by operator
TeamKalshiPolymarket USFanDuelDraftKings
DALDallas CowboysSPREADSpread K Best −3.5 +112 $100 → $212 Not available P Best −3.5 +113 $100 → $213 Not available FDNot listed DKNot listed
NYGNew York GiantsSPREADSpread K Best +3.5 -128 $100 → $178 Not available P Best +3.5 -127 $100 → $179 Not available FDNot listed DKNot listed
Total odds for Dallas Cowboys at New York Giants by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 47.5O/UTotal (Over/Under) K 47.5 -109 $100 → $191 Not available P Best 48.5 +108 $100 → $208 Not available FDNot listed DKNot listed
UUnder 47.5O/UTotal (Over/Under) K Best 47.5 -105 $100 → $195 Not available P 48.5 -122 $100 → $182 Not available FDNot listed DKNot listed
All markets odds for Dallas Cowboys at New York Giants by operator
TeamKalshiPolymarket USFanDuelDraftKings
DALDallas Cowboys K ML -164 SP −3.5 +112 TO o47.5 -109 P ML -161 SP −3.5 +113 TO o48.5 +108 FDNot listed DKNot listed
NYGNew York Giants K ML +143 SP +3.5 -128 TO u47.5 -105 P ML +143 SP +3.5 -127 TO u48.5 -122 FDNot listed DKNot listed
Broncos @ Chiefs
Moneyline odds for Denver Broncos at Kansas City Chiefs by operator
TeamKalshiPolymarket USFanDuelDraftKings
DENDenver BroncosMLMoneyline K +116 $100 → $216 Not available P Best +119 $100 → $219 Not available FDNot listed DKNot listed
KCKansas City ChiefsMLMoneyline K Best -134 $100 → $175 Not available P -134 $100 → $175 Not available FDNot listed DKNot listed
Spread odds for Denver Broncos at Kansas City Chiefs by operator
TeamKalshiPolymarket USFanDuelDraftKings
DENDenver BroncosSPREADSpread K Best +2.5 -109 $100 → $191 Not available P Best +2.5 -108 $100 → $192 Not available FDNot listed DKNot listed
KCKansas City ChiefsSPREADSpread K Best −2.5 -105 $100 → $195 Not available P Best −2.5 -104 $100 → $196 Not available FDNot listed DKNot listed
Total odds for Denver Broncos at Kansas City Chiefs by operator
TeamKalshiPolymarket USFanDuelDraftKings
OOver 43.5O/UTotal (Over/Under) K Best 43.5 -109 $100 → $191 Not available P 42.5 -122 $100 → $182 Not available FDNot listed DKNot listed
UUnder 43.5O/UTotal (Over/Under) K 43.5 -105 $100 → $195 Not available P Best 42.5 +108 $100 → $208 Not available FDNot listed DKNot listed
All markets odds for Denver Broncos at Kansas City Chiefs by operator
TeamKalshiPolymarket USFanDuelDraftKings
DENDenver Broncos K ML +116 SP +2.5 -109 TO o43.5 -109 P ML +119 SP +2.5 -108 TO o42.5 -122 FDNot listed DKNot listed
KCKansas City Chiefs K ML -134 SP −2.5 -105 TO u43.5 -105 P ML -134 SP −2.5 -104 TO u42.5 +108 FDNot listed DKNot listed
Patriots @ Seahawks · NBC
Final result and closing odds for New England Patriots at Seattle Seahawks by operator
TeamKalshiPolymarket USFanDuelDraftKings
NENew England Patriots10 K FINAL +149 Closed P FINAL +149 Closed FD FINAL +153 Closed DK FINAL +151 Closed
SEASeattle Seahawks13 K FINAL -171 Closed P FINAL -168 Closed FD FINAL -217 Closed DK FINAL -217 Closed
49ers @ Rams · Netflix · Melbourne
Final result and closing odds for San Francisco 49ers at Los Angeles Rams by operator
TeamKalshiPolymarket USFanDuelDraftKings
SFSan Francisco 49ers27 K FINAL +170 Closed P FINAL +173 Closed FD FINAL +162 Closed DK FINAL +138 Closed
LARLos Angeles Rams7 K FINAL -195 Closed P FINAL -195 Closed FD FINAL -230 Closed DK FINAL -197 Closed

Prices include taker fees: Kalshi 0.07×P×(1-P) per contract, Polymarket US 0.10% of trade value, FanDuel and DraftKings $0.02 per contract. Maker orders on Kalshi cost less. See our prediction market fees guide for the full breakdown.

Kickoff times are ET and subject to NFL flexible scheduling.

Prices are indicative and change constantly. Verify on the venue before trading.

Prices include trading fees where a fee model is configured for the operator.

Prices exclude trading fees. Fee models differ by venue, so a fee-free comparison favours whichever venue charges most.

Best available price outlined.

As of prices may be stale, verify before trading

Kalshi Deposit and trade at least $10 on Kalshi within your first 90 days and get a $25 trading bonus. The bonus is available for trade only and is not cashable. Must be used within 7 days. Eligible US states only.

Polymarket US 18+ Only. Restrictions and eligibility requirements apply. Not available in all jurisdictions. Trading is risky. 100% loss can occur. See polymarket.com/tos for more information. The Polymarket US App serves as an independent software provider and affiliate of Polymarket US and Polymarket Clearing, the CFTC-regulated exchange and clearing organization.

FanDuel Requires $1 trade over five days. The bonus itself is non-withdrawable, but winnings from bonus-funded trades are immediately withdrawable. If the bonus trade wins, you keep the winnings portion but not the original bonus stake. Must be 18+

DraftKings In partnership with DraftKings. T&Cs Apply. View full offer terms before trading. Full disclaimer here: Event Contract Trading is offered by DraftKings Predictions, a CFTC-registered Futures Commission Merchant and NFA member. Trading involves substantial risk of loss and is not suitable for everyone. Market availability varies. Eligibility restrictions apply. 1 per new DraftKings customer. $5+ first-time trade req. Max. $200 issued as non-withdrawable Predictions Dollars that expire in 1 year. Reward issued as $50 in Predictions Dollars every 7 days via click-to-claim for 21 days. Click-to-claims expire 7 days after issuance. 7 days = 168hrs. Terms: dkng.co/predictionspromo. Ends 9/20/26 at 11:59 PM ET. Sponsored by DK.

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Week 1 odds and predictions

New Orleans Saints @ Detroit Lions | Sunday, Sept. 13 | 1 p.m. ET | FOX | Ford Field, Detroit, MI |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Saints+6.5 (47¢)26% (+285)O 49.5 (52¢)
Lions-6.5 (54¢)75% (-300)U 49.5 (49¢)

Detroit is one of Week 1’s largest favorites, but New Orleans still has key availability questions. Cameron Jordan is out with a hamstring injury, while Alvin Kamara is questionable with a knee injury. Detroit placed running back Isiah Pacheco on injured reserve with a knee injury, and safeties Kerby Joseph and Brian Branch and center Cade Mays also will not be available for the opener.

Chicago Bears @ Carolina Panthers | Sunday, Sept. 13 | 1 p.m. ET | FOX | Bank of America Stadium, Charlotte, NC |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Bears-2.5 (55¢)60% (-150)O 46.5 (52¢)
Panthers+2.5 (46¢)40% (+150)U 46.5 (49¢)

Chicago is a slight road favorite against the defending NFC South champions. Wide receiver Rome Odunze is questionable with a calf injury, while the Bears remain without nickel cornerback Kyler Gordon, defensive lineman Shemar Turner and linebacker Noah Sewell after all three opened the season on reserve/PUP. Carolina added veteran tight end Darren Waller to Bryce Young’s receiving group, and he worked with the first team Sept. 2, but offensive lineman Brady Christensen must miss at least four games on injured reserve. For Caleb Williams, the opener is an early test of whether Chicago’s deep skill group can produce more consistently against a division winner.

Buffalo Bills @ Houston Texans | Sunday, Sept. 13 | 1 p.m. ET | CBS | NRG Stadium, Houston, TX |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Bills-1.5 (50¢)52% (-108)O 44.5 (50¢)
Texans+1.5 (51¢)48% (+108)U 44.5 (51¢)

Kalshi traders have Bills–Texans priced close to a coin flip. Houston lost wide receiver Jayden Higgins to a season-ending ACL tear and subsequently acquired Kayshon Boutte from New England. Buffalo listed running back Ty Johnson, defensive back Jordan Hancock and defensive lineman T.J. Sanders as questionable for Sunday. Houston carried no final injury designations into the game.

Baltimore Ravens @ Indianapolis Colts | Sunday, Sept. 13 | 1 p.m. ET | CBS | Lucas Oil Stadium, Indianapolis, IN |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Ravens-3.5 (46¢)61% (-156)O 47.5 (52¢)
Colts+3.5 (55¢)40% (+150)U 47.5 (49¢)

Indianapolis enters with Daniel Jones back after last season’s Achilles tear, while Baltimore begins the Jesse Minter era with Lamar Jackson leading Declan Doyle’s offense. Ravens wide receiver Zay Flowers received no final game designation, but defensive tackle Nnamdi Madubuike is out with a neck injury. Indianapolis listed linebacker Austin Ajiake as questionable and also will be without cornerback Cam Taylor-Britt, who must serve a one-game suspension.

Atlanta Falcons @ Pittsburgh Steelers | Sunday, Sept. 13 | 1 p.m. ET | FOX | Acrisure Stadium, Pittsburgh, PA |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Falcons+6.5 (53¢)30% (+233)O 40.5 (52¢)
Steelers-6.5 (48¢)71% (-245)U 40.5 (49¢)

Atlanta will start Cooper Rush after ruling out Tua Tagovailoa with an oblique injury and Michael Penix Jr. with a knee injury for Sunday. The Falcons’ edge depth is also reduced, with Jalon Walker on injured reserve after a season-ending ACL tear and 2025 sack leader James Pearce Jr. suspended for the first eight games. Pittsburgh has greater clarity at quarterback with Aaron Rodgers returning, although he will be directing Mike McCarthy’s new offense. Kalshi traders now have Pittsburgh favored by 6.5 points, while Atlanta’s win price fell from 32% Friday morning to 30% Saturday morning.

Tampa Bay Buccaneers @ Cincinnati Bengals| Sunday, Sept. 13 | 1 p.m. ET | FOX | Paycor Stadium, Cincinnati, OH |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Buccaneers+3.5 (50¢)37% (+170)O 49.5 (52¢)
Bengals-3.5 (50¢)64% (-178)U 49.5 (49¢)

Tristan Wirfs has returned to full-team work, reuniting Tampa Bay’s projected starting offensive line. Buccaneers wide receiver Jalen McMillan is doubtful with a knee injury, while linebacker Christian Rozeboom is questionable. Cincinnati defensive end Shemar Stewart is doubtful; Ja’Marr Chase and Tee Higgins received no final game designation.

New York Jets @ Tennessee Titans| Sunday, Sept. 13 | 1 p.m. ET | CBS | Nissan Stadium, Nashville, TN |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Jets+1.5 (52¢)49% (+104)O 38.5 (52¢)
Titans-1.5 (49¢)52% (-108)U 38.5 (49¢)

Geno Smith is back for a second Jets stint, while Tennessee continues with Cam Ward as its starter. Breece Hall received no final game designation, but the Jets ruled out edge rusher Joseph Ossai and wide receiver Tim Patrick. Tennessee linebacker Cedric Gray is also out. Kalshi traders have Jets–Titans priced close to a coin flip as Smith’s experience meets a younger Titans offense in Ward’s second season.

Cleveland Browns @ Jacksonville Jaguars | Sunday, Sept. 13 | 1 p.m. ET | CBS | EverBank Stadium, Jacksonville, FL |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Browns+9.5 (52¢)22% (+355)O 40.5 (49¢)
Jaguars-9.5 (49¢)79% (-376)U 40.5 (52¢)

Cleveland settled its quarterback competition Aug. 24, when Todd Monken named Deshaun Watson the Week 1 starter over Shedeur Sanders. Jacksonville will be without 2025 starting right guard Patrick Mekari for at least four games after placing him on injured reserve with a designation to return, and Ezra Cleveland has shifted from left guard to right guard. Kalshi traders have Jacksonville as the clear favorite, but its interior line will open with a new alignment in front of Trevor Lawrence.

Washington Commanders @ Philadelphia Eagles | Sunday, Sept. 13 | 4:25 p.m. ET | FOX | Lincoln Financial Field, Philadelphia, PA |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Commanders+5.5 (49¢)32% (+213)O 44.5 (48¢)
Eagles-5.5 (52¢)68% (-213)U 44.5 (53¢)

Washington will open without left tackle Laremy Tunsil and defensive tackle Jer’Zhan Newton, with Brandon Coleman back at tackle in Tunsil’s absence. The Commanders carried no final injury designations into Sunday. Philadelphia ruled out linebacker Jonathan Greenard with a pectoral injury and listed tight end Eli Stowers as questionable.

Green Bay Packers @ Minnesota Vikings| Sunday, Sept. 13 | 4:25 p.m. ET | CBS | US Bank Stadium, Minneapolis, MN |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Packers+2.5 (51¢)46% (+117)O 45.5 (52¢)
Vikings-2.5 (49¢)55% (-122)U 45.5 (49¢)

Minnesota will begin the season with Kyler Murray under center, while Green Bay remains without Micah Parsons and Josh Jacobs. Packers defensive tackle Warren Brinson and linebacker Ty’Ron Hopper missed Wednesday and Thursday practice; Aaron Banks, Javon Hargrave, Barryn Sorrell, Zach Bako-Bewele and Devonte Wyatt were limited Thursday, while Jordan Morgan improved to full participation. Green Bay ruled out defensive tackle Warren Brinson and listed Aaron Banks, Ty’Ron Hopper and Zach Bako-Bewele as questionable. Minnesota carried no final injury designations into Sunday.

Miami Dolphins @ Las Vegas Raiders | Sunday, Sept. 13 | 4:25 p.m. ET | FOX |Allegiant Stadium, Las Vegas, NV |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Dolphins+3.5 (54¢)40% (+150)O 40.5 (49¢)
Raiders-3.5 (47¢)60% (-150)U 40.5 (52¢)

Las Vegas named Kirk Cousins its Week 1 starting quarterback on Sept. 2, ending the camp competition with Fernando Mendoza and Aidan O’Connell. Miami opens the Jeff Hafley era with Malik Willis leading a young offense, while defensive tackle Kenneth Grant will be unavailable after going on injured reserve. Kalshi traders still have Las Vegas favored by 3.5 points, while Miami’s win price climbed from 37% to 40% overnight. Raiders Pro Bowl tight end Brock Bowers underwent a meniscus procedure and will miss the opener. The matchup now centers on whether Cousins can provide immediate stability against a Miami team beginning a broader reset under Hafley and Willis.

Arizona Cardinals @ Los Angeles Chargers| Sunday, Sept. 13 | 4:25 p.m. ET | CBS | SoFi Stadium, Inglewood, CA |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Cardinals+9.5 (51¢)19% (+426)O 46.5 (53¢)
Chargers-9.5 (50¢)81% (-426)U 46.5 (48¢)

Arizona’s backfield changed at roster cutdown when James Conner went on injured reserve with a designation to return. Arizona listed running back Jeremiyah Love as questionable and ruled out Isaiah Adams, Garrett Williams and Dadrion Taylor-Demerson. Another backfield absence would place additional pressure on Tyler Allgeier against Week 1’s largest favorite. Los Angeles is also adjusting up front, with Jake Slaughter taking over at center after Tyler Biadasz suffered a season-ending ACL tear.

Dallas Cowboys @ New York Giants | Sunday, Sept. 13 | 8:20 p.m. ET | NBC (SNF) | MetLife Stadium, East Rutherford, NJ |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Cowboys-2.5 (55¢)61% (-156)O 47.5 (51¢)
Giants+2.5 (46¢)40% (+150)U 47.5 (50¢)

This will be John Harbaugh’s first regular-season game as Giants head coach. Malik Nabers is questionable with a knee injury, while left tackle Andrew Thomas received no final game designation. Dallas ruled out running back Malik Davis. Nabers’ availability remains the Giants’ most important injury question against a revamped Cowboys secondary.

Denver Broncos @ Kansas City Chiefs | Monday, Sept. 14 | 8:15 p.m. ET | ESPN/ABC (MNF) | Arrowhead Stadium, Kansas City, MO |

TeamKalshi SpreadKalshi MoneylineKalshi O/U
Broncos+2.5 (50¢)45% (+122)O 43.5 (51¢)
Chiefs-2.5 (50¢)56% (-127)U 43.5 (50¢)

Patrick Mahomes was a full participant Thursday as Kansas City prepared for Monday night’s opener. Denver wide receiver Marvin Mims Jr. also practiced fully, while Chiefs safety Chamarri Conner and tackle Josh Simmons did not participate. Bo Nix returns for Denver after an ankle injury kept him out of last season’s AFC Championship Game. Kalshi traders continue to price Kansas City as only a slight favorite.

Missouri readers can compare current operators, legal status, and additional prediction markets in Missouri.

Notable Week 1 line moves

Among the 14 remaining Week 1 games, Kalshi’s board has produced six representative spread changes compared with DeFi Rate’s first archived snapshot on Aug. 9. Falcons-Steelers widened from Pittsburgh -3.5 to -6.5, Browns-Jaguars widened from Jacksonville -7.5 to -9.5, and Packers-Vikings widened from Minnesota -1.5 to -2.5. Jets-Titans narrowed from Tennessee -2.5 to -1.5, Cardinals-Chargers narrowed from Los Angeles -10.5 to -9.5, and Washington-Philadelphia widened from Philadelphia -4.5 to -5.5.

The largest moneyline change is in Falcons-Steelers. Atlanta fell from 41% to 30% while Pittsburgh climbed from 59% to 71%. Miami also rose from 35% to 40% against Las Vegas, and Minnesota moved from 50% to 55% while Green Bay fell from 50% to 46%.

Three other matchups have produced a probability move of at least three points on one side. New York rose from 44% to 49% while Tennessee fell from 55% to 52%, Dallas climbed from 58% to 61% while the Giants fell from 43% to 40%, and Baltimore eased from 64% to 61% while Indianapolis rose from 37% to 40%.

NFL Week 1 results

Seattle rallied from a 10-point second-half deficit to beat New England 13-10 in Wednesday night’s opener. The Seahawks scored all 13 of their points after halftime, tying the game on a fourth-quarter touchdown and winning on their final field goal. See the New England Patriots @ Seattle Seahawks market page for event details, and read our analysis of how Patriots-Seahawks prediction market volume jumped from $5.8 million to $105.5 million in 24 hours.

San Francisco answered the Rams’ second-quarter touchdown with 24 consecutive points to win 27-7 in Melbourne. The 49ers scored a touchdown in each of the final three quarters and held Los Angeles scoreless after halftime. See San Francisco 49ers vs. Los Angeles Rams for event details.

What to expect from NFL prediction markets this season

The 2026 season represents another significant step in the growth of NFL prediction market trading. For traders, the practical implication is that the NFL is no longer just a sportsbook sport. It is a fully functioning prediction market ecosystem with real liquidity, regulated infrastructure, and a growing suite of contracts that will expand as the season progresses. Readers can compare prediction market apps and review current NFL promos before choosing where to trade Week 1 contracts. 

With the preseason complete, trading focus is shifting from offseason futures to Week 1 game contracts. Prices can change quickly as official practice reports and active/inactive lists clarify player availability, while season-long futures will remain available throughout the regular season.

Related: See daily trading volume on NFL markets

About The Author
Christopher Feery, Author at DefiRate
Christopher Feery
Christopher has been writing professionally since 2014, with a focus on casinos and sports betting. After New Jersey legalized sports betting in 2018, he shifted his full attention to the gambling industry, joining Catena Media in 2021. He contributes in-depth analysis and guides on many igaming sites.